repertoire – Communicable Diseases Research

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19

코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 진단, 치료법,

AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responses

Article

Published on 2022-09-202022-11-15
Journal: PLoS Computational Biology
[Category] SARS, 진단,

Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire Profiling

De Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리

Review

Published on 2022-07-262022-09-11
Journal: Analytical Chemistry
[Category] MERS, 유전자 메커니즘, 진단,

[키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19
[DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review

Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina

아르헨티나 코르도바에서 생존자와 비생존자 COVID-19 환자의 SARS-CoV-2 계통발생 분석 및 비교 유전체학

Article

Published on 2022-07-142022-09-11
Journal: BMC Genomics
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis Analysis association B.1 both groups carried Clinical characteristics Clinical outcome clinical outcomes Comorbidities Comorbidity Comparative Comparative genomics Complete Córdoba coronavirus cough COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient COVID-19 patients Dyspnea Epidemiological study Evolution Evolution of SARS-CoV-2 Fever First wave functional Future Genes genome sequence Genome sequences genomes Genomic analysis genomic data groups Hospitalization in both groups incidence Infectious diseases Lineage majority Molecular epidemiology Mutation nasopharyngeal specimen Next-generation sequencing nine non-survivor Non-survivors Nsp3 outcomes pandemic Patient patients performed phylodynamic Prevalence Protein repertoire Research respiratory responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation SARS-CoV-2 pathogenesis SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. South America Specific specific mutation specific mutations Spike protein Spread survivor Survivors Symptom Symptoms the SARS-CoV-2 the Spike variant Variation was performed
[DOI] 10.1186/s12864-022-08756-6 PMC 바로가기 [Article Type] Article

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

대규모 용도 변경 노력에서 VERO-E6 세포에 대한 세포변성 SARS-CoV-2 스크리닝

Article

Published on 2022-07-132022-09-11
Journal: Scientific Data
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

Contrasting Epidemiology and Population Genetics of COVID-19 Infections Defined by Multilocus Genotypes in SARS-CoV-2 Genomes Sampled Globally

전 세계적으로 샘플링된 SARS-CoV-2 게놈의 다중 유전자형에 의해 정의된 COVID-19 감염의 대조 역학 및 인구 유전학

Article

Published on 2022-06-292022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법,

[키워드] aligned allele frequency alleles Alpha Amino acid amino acids Analysis Asia association Beta caused Cluster Clustering codon component continent continuous surveillance COVID-19 COVID-19 case COVID-19 incidence COVID-19 vaccine COVID-19 vaccines criteria deaths delta variant demographic data demographics demonstrated dependent on discriminant analysis distribution eight epidemiological Epidemiology Evolution Gamma Genetic genetics Genome genomes Genomic surveillance Genotype genotyping geographical regions GISAID help higher risk Inclusion inclusion criteria Intervention linkage Local loci majority matrix MONITOR multilocus Mutation mutation and transmission. North North America nucleocapsid older patient older patients ORF1ab ORF3a ORF8 persistence polymorphism Population populations predominant Prevalence reference genome repertoire Result risk of infection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 reference genome selected South America spatiotemporal Spread suggested the SARS-CoV-2 These data Transmission utility variant variants variants of concern Viral transmission VoC VOCs younger patient younger patients
[DOI] 10.3390/v14071434 PMC 바로가기 [Article Type] Article

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

유행성, 전염병, 풍토병: B 세포 레퍼토리 분석을 통해 SARS-CoV-2, 에볼라 및 호흡기 세포융합 바이러스에 대한 독특한 항바이러스 반응이 밝혀졌습니다

Article

Published on 2022-05-032022-09-12
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] age Analysis B cell Characteristics class-switch recombination (CSR) cohorts COVID-19 COVID-19 patient disease Ebola Ebolavirus Effects Endemic Epidemic event Evidence example Fever germinal centre heterogeneity humoral humoral immune response Hypothesis IgG1 IGH IGHV4-39 immature Immunity infections lack Lineage morbidity and mortality Mutation pandemic patients Recombination reflect repertoire repertoire. respiratory response risk RSV RSV (respiratory syncytial virus) SARS-CoV-2 Sequencing significant difference Support survivor switching unique vaccination Vaccine viral challenge viral infection Zaire
[DOI] 10.3389/fimmu.2022.807104 PMC 바로가기 [Article Type] Article

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

SARS-CoV-2 수용체 결합 도메인 인터페이스에서의 상위성과 백신 탈출에 대한 지루한 의미

Article

Published on 2022-04-262022-09-11
Journal: mBio
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody appear approach binding site closely resemble Complete coronavirus COVID-19 pandemic Delta delta variant destabilize dominance Effect Efficacy emergence epistasis escape escape mutants escape mutation Evolution Gamma Gamma variant host receptor include Interaction interface majority multiple mutation mutants Mutation mutations neutralizing antibody omicron Omicron variant Omicron variants overlap Protein protein structure protein structure modeling. RBD RBD mutation RBD mutations RBD-ACE2 Receptor-binding domain reduce reduced repertoire respiratory resulting risk Rosetta SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus single mutant Spike protein the RBD the receptor-binding domain the SARS-CoV-2 the spike protein unlikely Vaccine vaccine efficacy Vaccines variant variants variants of SARS-CoV-2 virus wild type wild-type SARS-CoV-2
[DOI] 10.1128/mbio.00135-22 PMC 바로가기 [Article Type] Article

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

B.1.617에 대한 효능을 유지하는 단일특이성 및 이중특이성 단일클론 SARS-CoV-2 중화 항체

Article

Published on 2022-03-282022-09-11
Journal: Nature Communications
[Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] analysis antibody B cell B cells B.1.617 B.1.617.2 binding patterns Breakthrough infection breakthrough infections caused clone complex conformations COVID-19 Critical cryo-EM structure cryo-EM structures death delta variant ectodomain Efficacy Epitopes expand facilitate functional generate humanized identify immunized in vivo inhibitory activity lead mAb mAbs maintain monoclonal monoclonal antibodies monoclonal antibody nanomolar affinity neutralize Neutralizing Neutralizing antibodies neutralizing antibody occur pathogen prefusion Prophylactic RBD Receptor binding domain repertoire SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants single cell sequencing Spike receptor binding domain spike trimer therapeutic therapeutic option Therapeutics translation Vaccine variants variants of concern virus
[DOI] 10.1038/s41467-022-29288-3 PMC 바로가기 [Article Type] Article

COVID-19 Pandemic: Escape of Pathogenic Variants and MHC Evolution

COVID-19 팬데믹: 병원성 변이체의 탈출 및 MHC 진화

Hypothesis

Published on 2022-02-282022-09-10
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), MERS, SARS, 변종,